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HIV Cure Research Workshop Report

Submitted by: Star One Public Relations

2011-12-31 00:05:40

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The last edition of the "International Workshop on HIV Persistence, Reservoirs and Eradication Strategies" took place in St Maarten, December 6-9, 2011. It is now time for the 210 participants to translate into their personal research what they have learned from this meeting.

Toulon, France (OPENPRESS) December 31, 2011 -- The workshop allowed to understand better fundamental mechanisms of viral persistence and virus-host interactions, and to envision future therapeutic strategies targeting HIV reservoirs. There are technological limitations to detecting HIV-infected resting memory CD4+ T-cells including: the huge volumes of blood needed by culture assay, the measure of defective viruses by PCR-based assays, and the lack of animal models. Additionally, recent studies indicate that two normal physiological processes involved in the maintenance of immunological memory, T-cell survival and homeostatic proliferation, likely contribute to the persistence of latently infected memory CD4 T-cells. In light of this evidence, researchers would like to find ways to recognize latently infected cells, activate them, leading to cell death or clearance by the immune system. Efforts are also ongoing to identify other cell populations than CD4+ T lymphocytes containing latent virus.

To design a cure for HIV infection, different or complementary approaches are needed to target residual virus in ART-treated patients. Some of them are already under testing, like vorinostat, of will be soon proposed for clinical trials, like anti-PD1 antibodies.

Finally, it is already shared by the scientific community that therapeutic approaches towards an HIV cure should be combinations of drugs to suppress inflammation, anti-PD1, chemokine antagonists, etc.

The 210 participants at the "International Workshop on HIV Persistence, Reservoirs and Eradication Strategies" discussed all these aspects in-depth. They were basic scientists, clinical researchers, firms' representatives, and patients' advocates, all highly involved in the search of an HIV cure.

HIV PERSISTENCE WORKSHOP HISTORY
The first 'HIV PERSISTENCE WORKSHOP' was launched in December 2003 under the initiatives of Dr Alain Lafeuillade (France), Pr Roger Pomerantz (USA) and Mario Stevenson (USA). The second edition took place in December 2005, the third in December 2007, the fourth in December 2007 and the fifth in scheduled December 6-9, 2011, each time in Saint Martin (West Indies). Saint Martin venue was initially motivated by its location near America and by the fact that it is in part governed by the French Republic.

Media Contact:
Alain Lafeuillade
CHITS
1208 Avenue Colonel Picot
83056 Toulon, Var, France
33-4-94616340
lafeuillade@orange.fr
Website: http://www.hiv-workshop.com/HIV-Cure-Research-Workshop-Report.htm .




Contact Info

Star One Public Relations
Phone: Not Given
Website: http://www.staronepr.com



Release Info

Metro Area: ALL REGIONS (Including International) Read More from this Metro Area
Country: France Read more from this Country
Industry: Medical: Research Read more from this Industry
Press Keywords: hiv, hiv cure, hiv research, hiv persistence, reservoirs, hiv reservoirs, workshop
Press Company: CHITS
Press Site: http://www.hiv-workshop.com/HIV-Cure-Research-Workshop-Report.htm




 


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